A-Bec ( abacavir 300 mg )

A-Bec (abacavir 300 mg) stands as the premier abacavir generic, is a nucleoside analogue and potent inhibitor of human immunodeficiency virus (HIV-1) reverse transcriptase. It is prescribed in conjunction with other antiretroviral agents to effectively treat HIV-1 infection.

Abacavir Dosage:

• Before initiating ABACAVIR, screen for the HLA-B*5701 allele.

• Adults: 600 mg daily, administered as either 300 mg twice daily or 600 mg once daily.

• Pediatric Patients Aged 3 Months and Older: Administered either once or twice daily. Dose should be calculated on body weight (kg) and should not exceed 600 mg daily.

• Patients with Hepatic Impairment: Mild hepatic impairment – 200 mg twice daily.

Abacavir side effects:

The accumulation of acid in the bloodstream, known as lactic acidosis, can occur in individuals taking ABACAVIR. Lactic acidosis is a severe medical emergency that can be fatal. If you experience any of the following symptoms, which may indicate lactic acidosis, contact your healthcare provider immediately: profound weakness or fatigue, unusual muscle pain, intense cold sensation in the arms and legs, dizziness or lightheadedness, difficulty breathing, abdominal pain accompanied by nausea and vomiting, or rapid or irregular heartbeat.

It is important to note that serious liver problems can also occur in individuals using ABACAVIR, and in some cases, these issues can lead to death. ABACAVIR usage may result in an enlarged liver (hepatomegaly) and the accumulation of fat in the liver (steatosis). Should you experience any of the following signs of liver problems, contact your healthcare provider right away: yellowing of the skin or the white part of the eyes (jaundice), dark or "tea-colored" urine, light-colored stools, prolonged loss of appetite, nausea, or pain, aching, or tenderness on the right side of the stomach area.

It's worth noting that females or individuals who are significantly overweight (obese) may have a higher risk of developing lactic acidosis or experiencing serious liver problems while taking ABACAVIR.

Commencing HIV-1 medication can result in changes to your immune system, known as Immune Reconstitution Syndrome. As your immune system strengthens, it may begin to combat infections that have been dormant in your body for an extended period. If you encounter new symptoms after initiating ABACAVIR treatment, promptly inform your healthcare provider.

Furthermore, the use of HIV-1 medications, including ABACAVIR, may increase the risk of heart attack (myocardial infarction). It is crucial to be aware of this potential risk.

The most frequently observed side effects of ABACAVIR in adults include nausea, headaches, general malaise, fatigue, vomiting, and unsettling dreams or sleep difficulties. In children, the most common side effects of ABACAVIR are fever and chills, nausea, vomiting, rash, and ear, nose, or throat infections.