Apigat (Apixaban 5mg)

Apigat 5mg also known as best apixaban generic is a factor Xa inhibitor, is prescribed for the following conditions:

• Stroke and systemic embolism prevention: In patients with nonvalvular atrial fibrillation.
• DVT prophylaxis: To prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) after hip or knee replacement surgery.
• DVT and PE treatment: For treating DVT and PE and reducing the risk of recurrence after initial therapy.

Dosage Guidelines:

1.      Stroke and systemic embolism risk reduction in nonvalvular atrial fibrillation:
2.      DVT prophylaxis after hip or knee replacement surgery:
3.      DVT and PE treatment:
4.      Risk reduction of recurrent DVT and PE:

• Standard dose: 5 mg orally twice daily.
• Adjusted dose: 2.5 mg orally twice daily for patients with any two of the following:
  • Age ≥ 80 years.
  • Body weight ≤ 60 kg.
  • Serum creatinine ≥ 1.5 mg/dL.

• 2.5 mg orally twice daily.

• Initial dose: 10 mg orally twice daily for 7 days.
• Maintenance dose: 5 mg orally twice daily.

• 2.5 mg orally twice daily.

Side Effects and Precautions:

General Risks:

• Increased clot risk if stopped suddenly: Stopping Apixaban without medical advice raises the chance of clot formation and stroke. Discuss discontinuation with your doctor.
• Risk of bleeding: As a blood thinner, Apixaban increases bleeding risks, which can be serious or life-threatening.

Common Symptoms to Monitor:

Contact your doctor if you experience:

• Unexpected or prolonged bleeding (e.g., gums, nosebleeds, heavy menstrual bleeding).
• Unusual bruising or signs of internal bleeding (e.g., red/pink/brown urine, tar-like stools, blood in vomit).
• Persistent dizziness, severe headaches, or joint swelling.

Drug Interactions:

Taking Apixaban alongside the following increases bleeding risk:

• Aspirin or aspirin-based products.
• Long-term NSAID use.
• Blood thinners like warfarin or heparin.
• SSRIs, SNRIs, or other clot prevention medications.

Special Warnings:

• Not suitable for patients with artificial heart valves or antiphospholipid syndrome (APS).
• Spinal/epidural blood clots: Patients undergoing spinal procedures with Apixaban may develop clots causing paralysis. Symptoms include tingling, numbness, or muscle weakness in the legs.

Allergic Reactions:

Seek emergency help if you experience:

• Chest pain, facial or tongue swelling, difficulty breathing, or fainting.

Other Considerations:

• Apixaban is not recommended for patients with a history of spinal surgery or complex spinal punctures.
• Notify your healthcare provider if you develop any skin rash or discomfort that persists.

Important Note:

This is not a comprehensive list of potential side effects. Discuss any concerns with your doctor or pharmacist for further information.