Ibrunat (Ibrutinib 140)

Ibrunat (Ibrutinib 140mg) is a Ibrutinib generic kinase inhibitor indicated for the treatment of adult patients with:

• Mantle cell lymphoma (MCL) who have received at least one prior therapy.

Accelerated approval was granted for this indication based on overall response rate. Continued approval for this indication may be contingentupon verification and description of clinical benefit in a confirmatory trial.

• Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) .

• Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) with 17p deletion .

• Waldenström’s macroglobulinemia (WM) .

• Marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy. Accelerated approval was granted for this indication based on overall response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

• Chronic graft versus host disease (cGVHD) after failure of one or more lines of systemic therapy

Ibrutinib cost in India:

Ibrunat (Ibrutinib 140mg) cost in India is only 5% of the Ibrutinib in other country .

Ibrutinib Dosage

• MCL and MZL: 560 mg taken orally once daily (four 140 mg capsules once daily)

• CLL/SLL, WM, and cGVHD: 420 mg taken orally once daily (three 140 mg capsules once daily).Capsules should be taken orally with a glass of water. Do not open, break, or chew the capsules

Ibrutinib side effects：

The most common side effects of Ibrutinib in adults with B-cell malignancies (MCL, CLL/SLL, WM and MZL)

include:

o diarrhea  o muscle and bone pain o rash  o bruising  o nausea o tiredness o fever

The most common side effects of Ibrutinib in adults with cGVHD include:

o tiredness o bruising o diarrhea o mouth sores (stomatitis) o muscle spasms  o nausea  o pneumonia

Diarrhea is a common side effect in people who take Ibrutinib. Drink plenty of fluids during treatment with Ibrutinib to help reduce your risk of losing too much fluid (dehydration) due to diarrhea. Tell your healthcare provider if you have diarrhea that does not go away.
These are not all the possible side effects of Ibrutinib.

For more Prescribing information，please check with our supporter for  “FDA Prescribing Information”.