Loncil ( Trifluridine 15 mg / Tipiracil 6.14 mg )

Loncil (Trifuridine/Tipiracil) is a fixed-dose combination tablet comprising trifuridine, an antineoplastic nucleoside analogue, and tipiracil, a thymidine phosphorylase inhibitor.

Loncil (Trifuridine/Tipiracil) has recently been granted an additional indication in the USA for the treatment of metastatic gastric cancer, including gastrosophageal junction adenocarcinoma, in patients who have been previously treated with at least two systemic treatment regimens, and has received a positive opinion for this indication in the EU (European Union).

Loncil (Trifuridine/Tipiracil) Dosage

The recommended dosage of Trifluridine and Tipiracil is 35 mg/m2 up to a maximum of 80 mg per dose (based on the Trifluridine component) orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle until disease progression or unacceptable toxicity. Round dose to the nearest 5 mg increment. Instruct patients to swallow the tablet whole. Instruct patients not to retake doses of Trifluridine and Tipiracil that are vomited or missed and to continue with the next scheduled dose. Trifluridine and Tipiracil is a cytotoxic drug. Follow applicable special handling and disposal procedures.

Loncil (Trifuridine/Tipiracil) price

Trifluridine cost in other countries is about $4,200, Trifluridine Tipiracil price in India is only 7%.

Trifluridine/Tipiracil side effects

The most common side effects of Loncil when used in combination with bevacizumab include:

•          Low blood counts
•          Tiredness and weakness
•          Nausea
•          Certain abnormal liver function blood tests
•          Decreased salt (sodium) in your blood
•          Diarrhea
•          Stomach-area (abdominal) pain
•          Decreased appetite

The most common side effects of Loncil when used alone include:

•          Low blood counts
•          Tiredness and weakness
•          Nausea
•          Decreased appetite
•          Diarrhea
•          Vomiting
•          Stomach-area (abdominal) pain
•          Fever

How to manage Loncil side effects

Your healthcare provider may have ways to help manage some of the side effects of treatment. This could include adjusting your treatment plan by changing your dosage of Loncil or stopping treatment. After discussing any side effects, your healthcare provider may prescribe medications or recommend certain lifestyle changes or non-prescription medications that can help.

The following information may also be helpful to you in managing some of these side effects that may occur with Loncil alone or in combination with bevacizumab while under the care of your healthcare provider.