Niraparix (Niraparib)

Niraparix also known as generic Niraparib, is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated:

1.  for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy.
2. for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy.
3.  For the treatment of adult patients with advanced ovarian, fallopian tube, or primary peritoneal cancer who have been treated with 3 or more prior chemotherapy regimens and whose cancer is associated with homologous recombination deficiency (HRD) positive status defined by either:                                                                                                          • a deleterious or suspected deleterious BRCA mutation, or                                                • genomic instability and who have progressed more than 6 months after response to the last platinum-based chemotherapy. Select patients for therapy based on an FDA-approved companion diagnostic for Niraparib

Niraparib Cost

Niraparib Price is 23901USD per 90 Capsules. Niraparib cost in India is only 6% of it.

Niraparib Dosage

1. First-line maintenance treatment of advanced ovarian cancer:

       • For patients weighing <150,000/mcL, the recommended dosage is 200 mg taken orally once daily.

       • For patients weighing ≥77 kg (≥170 lbs) AND a platelet count ≥150,000/ mcL, the recommended dosage is 300 mg taken orally once daily.

2. For other indications: The recommended dosage is 300 mg taken orally once daily.

3.  Continue treatment until disease progression or unacceptable adverse reaction.

4.  Niraparib may be taken with or without food.

5.   For adverse reactions, consider interruption of treatment, dose reduction, or dose discontinuation

     • For patients with moderate hepatic impairment, reduce the starting dosage of niraparib to 200 mg once daily. 

Niraparib Side Effects：

The most common side effects of Niraparib include:

• heart not beating regularly • changes in liver function or other blood tests • nausea • pain in your muscles and back • constipation • headache • vomiting • dizziness • pain in the stomach area • change in the way food tastes • mouth sores • trouble sleeping • diarrhea • anxiety • indigestion or heartburn • sore throat • dry mouth • shortness of breath • tiredness • cough • loss of appetite • rash • urinary tract infection • changes in the amount or color of your urine

Your healthcare provider may change your dose, temporarily stop treatment, or permanently stop treatment with Niraparib if you have certain side effects.

These are not all the possible side effects of Niraparib.

For more Prescribing information，please ask for our customer service for the → “FDA Prescribing Information”.